Zebrafish made to grow pre-hands instead of fins








































PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.













Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.












Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.












One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).












"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.


















































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Youths have similar ideals to govt, says ESM Goh






SINGAPORE: Singapore youths generally have the same ideals as that of the government, observed Emeritus Senior Minister Goh Chok Tong at the end of a national conversation session at the Marine Parade constituency.

Mr Goh said this will make it easier for the government to work together with the generation of the future.

"Supposing they come up with very different ideals from what we think should be for the prosperity and stability of Singapore. It's going to be very troublesome," he said.

"Supposing they had all argued about welfare state and so on, then that's very troublesome for us because we know that without resources, without economic growth and so on, a welfare state will lead us to ruins."

Some of the goals set by participants during the conversation with Marine Parade residents included a more cohesive society and more sustainable economic growth.

The 45 participants comprised youths and working adults.

Mr Goh felt that the society has, in recent years, been drifting without a clear sense of direction.

He added that having the same ideals does not mean goals can be reached if the society is divided.

Mr Goh said Singapore has never been more politically divided, so the Singapore Conversation is a very serious effort to build a new compact between the people and the government.

"The worry is as we emphasise more freedom for the people, (society) becomes more cosmopolitan, takes in more foreigners, immigrants and so on, (and) our society begins to loosen as a result of these new trends," he said.

"The old (generation) is getting smaller in proportion. The young (generation) is getting bigger, with different experiences... and if they don't get a new sense of bonding in working as a group, can you imagine how we move into the future?"

Mr Goh also pointed out even though ideals may be similar, young Singaporeans may disagree with the processes and priorities in policy-making.

Youths felt that at this stage of the conversation, ideals that surface would naturally be similar to the government. But they believed there is still space for disagreements.

"When the conversation is couched in very generic themes and terms, of course, we have the same broad general ideals and there is a consensus," said Chris Lim, a participant at the session.

"But when the minute details of policies are discussed, that's when differences will start to appear, in the ways of how we do it. This is a question that remains to be answered in the course of our national conversation."

This is the first time Mr Goh has attended the national conversation session.

He has been conducting several community conversations with his residents at Marine Parade.

Mr Goh explained that these conversations were more unstructured, where residents could discuss policy issues.

Lawrence Wong, committee member of Our Singapore Conversation, said he is satisfied with the progress and outreach, three months after the initiative started.

Mr Wong was also present at the session in Marine Parade.

He said: "We've been trying to reach out to as broad spectrum of society as possible, and I think we've had very good representation of people who come enthusiastically to share, and we've got very good ideas. There's certainly more that we can do."

Separately, at a session of Our Singapore Conversation held with the Malay Muslim community at Bukit Batok East, participants raised the issue of cultivating patriotism in every Singaporean, especially the younger generation.

"What is important to me also is that they talk about patriotism, which is something I did not find in the other conversations," said Minister of State for Social and Family Development Halimah Yacob.

"In this conversation, they say it is important within the context of building a strong national identity, reinforcing multi-culturalism, multi-racialism, that we are patriotic Singaporeans and how we continue to project that."

- CNA/xq



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Google's Ray Kurzweil hire could yield some good returns



Ray Kurzweil signing copies of his book, "The Singularity"



(Credit:
Dan Farber)


Google has brought on futurist and artificial intelligence expert Ray Kurzweil as director of engineering, and there could be some real returns on the company's high-profile hire.



In a statement, Kurzweil confirmed that he'd be joining Google. He noted that his interest in reading technology, artificial intelligence, driving
cars and those other things from the Jetsons lines up nicely with Google's efforts.



He said:



Google has demonstrated self-driving cars, and people are indeed asking questions of their
Android phones. It's easy to shrug our collective shoulders as if these technologies have always been around, but we're really on a remarkable trajectory of quickening innovation, and Google is at the forefront of much of this development.


Will Kurzweil be more than just a figurehead? Probably. Google will get some returns on its investment in Kurzweil for sure. Here are some of the positive side effects from Google's latest hire.



Talent and recruiting engineers. There aren't enough engineers to keep tech giants like Google, Microsoft, Apple and others happy. Saying you report to a futurist---even indirectly---will have credibility beyond stock options for most engineers.


Data centers, networks and algorithms need machine learning. Kurzweil's ideas get noticed because he's ahead of the curve and he focuses on simple practical systems. However, machine learning has implications for the network, Google's algorithms and the data center. Look no further than IBM and Watson for examples of how machine learning can have broad implications. Should Kurzweil boost machine learning, Google is likely to be able to draw a straight line between its infrastructure and its high-profile hire.


Language processing has big mobile implications. Kurzweil's knowhow could on reading and talking machines could easily make its way into Android, which is already becoming very helpful on many fronts.


Google's buzz-o-meter. Kurzweil's work can easily be applied to the company's efforts for self-driving cars and its high-tech glasses that could become popular at some point. Kurzweil gives Google some science fiction becomes reality cred. The buzz is hard to measure, but it's certainly not a bad perk for the company.


In his book, "The Singularity Is Near: When Humans Transcend Biology," Kurzweil offered his view of how science fiction becomes reality:


"In this new world, there will be no clear distinction between human and machine, real reality and virtual reality. We will be able to assume different bodies and take on a range of personae at will. In practical terms, human aging and illness will be reversed; pollution will be stopped; world hunger and poverty will be solved. Nanotechnology will make it possible to create virtually any physical product using inexpensive information processes and will ultimately turn even death into a soluble problem."


Kurzweil expects that artificial intelligence will develop far beyond the human mind in a few decades, leading to what he calls "The Singularity," in which technology changes profoundly alter human history. "The implications include the merger of biological and nonbiological intelligence, immortal software-based humans, and ultra-high levels of intelligence that expand outward in the universe at the speed of light," he wrote.


This story first appeared on ZDNet. Additional reporting by Dan Farber.


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Space Pictures This Week: Frosty Mars, Mini Nile, More

Photograph by Mike Theiss, National Geographic

The aurora borealis, also known as the northern lights, illuminates the Arctic sky in a recent picture by National Geographic photographer Mike Theiss.

A storm chaser by trade, Theiss is in the Arctic Circle on an expedition to photograph auroras, which result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere.

After one particularly amazing show, he wrote on YouTube, "The lights were dancing, rolling, and twisting, and at times looked like they were close enough to touch!" (Watch his time-lapse video of the northern lights.)

Published December 14, 2012

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School Shooting: Officials Seek Details on Gunman













The FBI is in at least three states interviewing relatives and friends of the elementary school gunman who killed 20 children, seven adults and himself, trying to put together a better picture of the shooter and uncover any possible explanation for the massacre, ABC News has learned.


The authorities have fanned out to New Jersey, Connecticut and Massachusetts to interview relatives of Adam Lanza, 20, and his mother, who was one of Lanza's shooting victims.


CLICK HERE for full coverage of the tragedy at the elementary school.


The victims died Friday when Lanza invaded Sandy Hook Elementary School in Newtown, Conn., and sprayed staff and students with bullets, officials said. Lanza also was found dead in the school.


Lt. Paul Vance said 18 children died in the school and two more died later in a hospital.


Six adults also were slain, bringing the total to 26. Among them was the school's principal, Dawn Hochsprung, multiple sources told ABC News. Another adult victim was teacher Vicki Soto, her cousin confirmed.


In addition to the casualties at the school, Lanza's mother, Nancy Lanza, was killed in her home, federal and state sources told ABC News.


According to sources, Lanza shot his mother in the face, then left his house armed with at least two semi-automatic handguns, a Glock and a Sig Sauer, and a semi-automatic rifle. He was also wearing a bulletproof vest.


READ: Connecticut Shooter Adam Lanza: 'Obviously Not Well'








Newtown Teacher Kept 1st Graders Calm During Massacre Watch Video











Newtown School Shooting: What to Tell Your Kids Watch Video





Lanza then drove to the elementary school and continued his rampage, authorities said.


It appeared that Lanza died from what was believed to be a self-inflicted gunshot wound. The rifle was found in his car.


"Evil visited this community today," Gov. Dan Malloy said at a news conference Friday evening.


CLICK HERE for more photos from the scene.


In the early confusion surrounding the investigation, federal sources initially identified the suspect as Adam's older brother Ryan Lanza, 24. Identification belonging to Ryan Lanza was found at the shooting scene, federal sources told ABC News.


Ryan Lanza soon took to Facebook to say he was alive and not responsible for the shooting. He later was questioned by police.


During the rampage, first-grade teacher Kaitlin Roig, 29, locked her 14 students in a class bathroom and listened to "tons of shooting" until police came to help.


"It was horrific," Roig said. "I thought we were going to die."


She said that the terrified kids were saying, "I just want Christmas. ... I don't want to die. I just want to have Christmas."


A tearful President Obama said Friday that there was "not a parent in America who doesn't feel the overwhelming grief that I do."


The president had to pause to compose himself after saying these were "beautiful little kids between the ages of 5 and 10."


As he continued with his statement, Obama wiped away tears from each eye. He has ordered flags flown as half staff.


It is the second worst mass shooting in U.S. history, exceeded only by the Virginia Tech shooting in 2007 when 32 were killed before the shooter turned the gun on himself. The carnage in Connecticut exceeded the 1999 Columbine High School shooting in which 13 died and 24 were injured.


Friday's shooting came three days after masked gunman Jacob Roberts opened fire in a busy Oregon mall, killing two before turning the gun on himself.


The Connecticut shooting occurred at the Sandy Hook Elementary School, which includes 450 students in grades K-4. The town is located about 12 miles east of Danbury, Conn.


The massacre prompted the town of Newtown to lock down all its schools and draw SWAT teams to the school, authorities said.






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Satellite upgrade should let planes slash emissions









































A CONSTELLATION of next-generation communications satellites has a surprise in store for the environment. When Iridium Communications begins launching replacement orbiters in 2015, it will do much more than upgrade its satphone services. Piggybacking on the satellites will be a set of transmitters that could revolutionise long-haul flight, save airlines billions of dollars worth of fuel and prevent millions of tonnes of carbon emissions.












For the first time, these devices, known as ADS-B transponders, will enable air traffic controllers to locate aircraft that are far out over oceans, remote deserts or the poles where there is no radar coverage. On top of the greater safety this offers airlines if a plane gets into trouble, say, it will also let controllers pack planes in closer together along optimal flight paths, which will cut carbon emissions.












The ADS-B radio transmitting system is designed to replace expensive, unreliable and low-range radar tracking. It bundles an aircraft's call sign, GPS position, speed and altitude into 112-bit digital packets, which are broadcast continually from the aircraft to the control stations.












But like today's radar, ADS-B radio packets have limited range. "If you're way out in the Pacific or over the North Pole no one's going to pick it up," says Dan Mercer of Iridium Communications. So the transponders piggybacking on the new satellites will pick up those signals and beam them back down to Earth. "For the first time, they'll have total vision of the aircraft at all times," Mercer says.












To avoid potential collisions, planes on long-haul routes out over the oceans currently have to fly quite a long way apart. And only some planes can fly in air lanes with kind tailwinds, while others have to push through less-favourable air currents. "If air traffic control can see where aircraft are precisely, they can fly them all closer together and on the most efficient routes. So they will save fuel and cut emissions," says Mercer.


















A study commissioned by Iridium found that between the service's proposed start in 2017 and 2030, the technology should save airlines about $7 billion on fuel and cut carbon dioxide and nitrogen oxide emissions by 35 million tonnes. Another projection that looked at just North Atlantic flights says orbital ADS-B will save airlines $110 million in fuel and 300,000 tonnes in emissions in 2018 alone.












The system can "improve the efficiency of oceanic air traffic management by reducing aircraft separation distances and allowing greater route optimisation", says Pauline Lamb, operations director of National Air Traffic Services in Prestwick, UK. She adds that her organisation is working to fully understand the benefits it will provide.












Meanwhile, one of the world's largest air traffic management firms, Nav Canada of Ottawa, Ontario, has formed Aireon, a joint venture with Iridium. Aireon will operate and sell the transponder service to airlines and air traffic control providers. In combination with other measures - such as use of lighter carbon fibre planes and more efficient engines - Iridium's move should help aviation fight its environmental corner.




















































If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.









































































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Two dead, 10 missing after South Korea barge capsizes






SEOUL: Two construction workers were confirmed killed late Friday and 10 others missing after a barge carrying a crane capsized off South Korea's southeast coast, the coastguard said.

The 2,600-ton barge sank off the city of Ulsan after the 80-metre (264-foot) crane collapsed, Yonhap news agency quoted coastguard officials as saying.

Twelve people have so far been rescued with two others confirmed dead, and a search is underway for the 10 missing workers.

The accident happened during construction of a new port.

- AFP/lp



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Get a Sceptre 42-inch HDTV for $299 shipped



It was almost two years ago to the day that I wrote about a 32-inch TV selling for $299 (a Sceptre, in fact), and what a big deal that was.


Now you can get a significantly larger screen for exactly the same price: For a limited time, and while supplies last, Walmart has the Sceptre X425BV-FHD 42-inch LCD HDTV for $299, plus sales tax where applicable. Shipping is free, or you can opt for free in-store pickup. Either way, you're assured of getting it on or before Dec. 24.


(Note: This deal started yesterday, and I don't know when it's scheduled to expire, so I apologize in advance if it suddenly disappears today. It's been known to happen.)


As you might expect given the price point, this is a lower-end TV, with a 60Hz refresh rate and a standard (i.e. non-LED) LCD. The refresh rate doesn't bother me in the slightest; I actually prefer it to most of the 120Hz and 240Hz models I've seen, which invariably produce that hideous soap-opera effect.


As for the rest of the specs, they're about what you'd expect: three HDMI inputs, a 5ms response time, and, um, a remote. So, yeah, pretty basic. If you want to "smarten" this TV, you'll need to plug in a Roku box,
Apple TV, or the like. (Roku deal of the day: the refurbished Roku 2 XS for $59.99 shipped. The same model sells new for $99.99.)


When you're looking at an off-brand TV like this one, it's always a good idea to peruse the user reviews. Fortunately, Walmart has lots of them -- over 400 -- and the vast majority rated the Sceptre four or five stars. The general consensus: this model delivers considerable bang for the buck.


And, hey, it's Walmart, so it's easy enough to return the unit if you're not happy with it. Contrast that with buying from a place that's strictly mail-order, where you're probably on the hook for return shipping. Just saying.


I've had very good luck with off-brand models like this. Your mileage may vary, of course, but if you're looking for a decent-size TV for a crazy-good price, have a look.


Bonus deal: And if you're looking for a decent-size monitor for a crazy-good price, today only, OfficeMax has the AOC E2460SWD 24-inch for $119.99 shipped (plus sales tax where applicable). That's one of the lowest prices I've ever seen for a monitor of this size, meaning it will likely sell out quickly.


Bonus deal No. 2: I continue to be a huge fan of Ebates, which pays you back a percentage of pretty much everything you buy online. And the site is currently offering double cash back from various stores -- including Walmart, which is now at two percent. And you can get 3 percent back on OfficeMax purchases. It may not seem like much, but believe me, it adds up. If you haven't yet signed up for Ebates, you can do so for free right here.


Bonus deal No. 3: Do you own an
iPad and dislike pigs? (I know, the two seem to go hand-in-hand.) For a limited time, all the Angry Birds games for iPad (including Star Wars, Seasons, Rio, and Bad Piggies) are on sale for 99 cents each. They're usually $2.99 each.


Deals found on The Cheapskate are subject to availability, expiration, and other terms determined by sellers.


Curious about what exactly The Cheapskate does and how it works? Read our FAQ.


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Global Checkup: Most People Living Longer, But Sicker


If the world's entire population went in for a collective checkup, would the doctor's prognosis be good or bad? Both, according to new studies published in The Lancet medical journal.

The vast collaborative effort, called the Global Burden of Diseases, Injuries, and Risk Factors Study 2010, includes papers by nearly 500 authors in 50 countries. Spanning four decades of data, it represents the most comprehensive analysis ever undertaken of health problems around the world.

It reveals that, globally, we're living longer but coping with more illness as adults. In 1990, "childhood underweight"—a condition associated with malnutrition, measles, malaria, and other infectious diseases—was the world's biggest health problem. Now the top causes of global disease are adult ailments: high blood pressure (associated with 9.4 million deaths in 2010), tobacco smoking (6.2 million), and alcohol use (4.9 million).

First, the good news:

We're living longer. Average life expectancy has risen globally since 1970 and has increased in all but eight of the world's countries within the past decade.

Both men and women are gaining years. From 1970 to 2010, the average lifespan rose from 56.4 years to 67.5 years for men, and from 61.2 years to 73.3 years for women.

Efforts to combat childhood diseases and malnutrition have been very successful. Deaths in children under five years old declined almost 60 percent in the past four decades.

Developing countries have made huge strides in public health. In the Maldives, Bangladesh, Bhutan, Iran, and Peru, life expectancy has increased by more than 20 years since 1970. Within the past two decades, gains of 12 to 15 years have occurred in Angola, Ethiopia, Niger, and Rwanda, an indication of successful strategies for curbing HIV, malaria, and nutritional deficiencies.

We're beating many communicable diseases. Thanks to improvements in sanitation and vaccination, the death rate for diarrheal diseases, lower respiratory infections, meningitis, and other common infectious diseases has dropped by 42 percent since 1990.

And the bad:

Non-infectious diseases are on the rise, accounting for two of every three deaths globally in 2010. Heart disease and stroke are the primary culprits.

Young adults aren't doing as well as others. Deaths in the 15 to 49 age bracket have increased globally in the past 20 years. The reasons vary by region, but diabetes, smoking, alcohol, HIV/AIDS, and malaria all play a role.

The HIV/AIDS epidemic is taking a toll in sub-Saharan Africa. Life expectancy has declined overall by one to seven years in Zimbabwe and Lesotho, and young adult deaths have surged by more than 500 percent since 1970 in South Africa, Botswana, Zambia, and Zimbabwe.

We drink too much. Alcohol overconsumption is a growing problem in the developed world, especially in Eastern Europe, where it accounts for almost a quarter of the total disease burden. Worldwide, it has become the top risk factor for people ages 15 to 49.

We eat too much, and not the right things. Deaths attributable to obesity are on the rise, with 3.4 million in 2010 compared to 2 million in 1990. Similarly, deaths attributable to dietary risk factors and physical inactivity have increased by 50 percent (4 million) in the past 20 years. Overall, we're consuming too much sodium, trans fat, processed meat, and sugar-sweetened beverages, and not enough fruits, vegetables, whole grains, nuts, fiber, calcium, and omega-3 fatty acids.

Smoking is a lingering problem. Tobacco smoking, including second-hand smoke, is still the top risk factor for disease in North America and Western Europe, just as it was in 1990. Globally, it's risen in rank from the third to second leading cause of disease.

To find out more and see related charts and graphics, see the Institute for Health Metrics and Evaluation, which led the collaboration.


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Critics Faulted Rice's Work on Benghazi, Africa













United Nations Ambassador Susan Rice removed herself from possible consideration as secretary of state after becoming yet another player in the divide between the left and right.


Rice, who withdrew her name Thursday, has faced months of criticism over how she characterized the Sept. 11 attack on a U.S. consulate in Benghazi, Libya. She also has come under fire for her approach to dealing with African strongmen.


Rice became a target for conservatives when she went on Sunday morning current affairs shows such as ABC News' "This Week" following the Benghazi attack and failed to characterize it as a pre-meditated act of terror. Instead, she said it was a spontaneous response to an anti-Islam film produced in the United States and cited in the region as an example of anti-Islamicism in the West.


After it became clear that Rice's assertions were untrue and elements of the Obama administration may have known that to be the case, Republican Sens. Lindsey Graham, John McCain and Kelly Ayotte said they would do whatever they could to block Rice's possible nomination to replace Hillary Clinton as secretary of state.








Susan Rice Withdraws From Consideration for Secretary of State Watch Video









GOP Senators 'Troubled' After Meeting With Ambassador Rice Watch Video









President Obama to Senator McCain: 'Go After Me' Watch Video





"This is about the role she played around four dead Americans when it seems to be that the story coming out of the administration -- and she's the point person -- is so disconnected to reality, I don't trust her," Graham said. "And the reason I don't trust her is because I think she knew better. And if she didn't know better, she shouldn't be the voice of America."


Members of the administration defended Rice. At his testimony before Congress, Gen. David Petraeus, the former CIA director, said Rice was speaking from unclassified talking points given to her by the CIA.


Senate Intelligence Committee Chairwoman Dianne Feinstein, D-Calif., reiterated what Petraeus said outside his closed-door hearing before the Senate.


"The key is that they were unclassified talking points at a very early stage. And I don't think she should be pilloried for this. She did what I would have done or anyone else would have done that was going on a weekend show," Feinstein said. "To say that she is unqualified to be secretary of state, I think, is a mistake. And the way it keeps going, it's almost as if the intent is to assassinate her character."


Minutes after she announced her withdrawal from the process, Graham tweeted, "I respect Ambassador Rice's decision."


McCain's office released a paper statement saying, "Senator McCain thanks Ambassador Rice for her service to the country and wishes her well. He will continue to seek all the facts surrounding the attack on our consulate in Benghazi that killed four brave Americans."


Over the last few weeks, criticism of Rice had grown beyond her response to Benghazi to include a closer scrutiny of her work in Africa, where she had influence over U.S. policy during the Clinton administration.


Critics of her Africa dealings were not partisan -- but included human rights workers, journalists and some Africans themselves.


Among the most serious critiques was the accusation that she actively protected Rwandan President Paul Kagame and senior members of his government from being sanctioned for funding and supporting the rebels that caused Eastern Congo's recent violence.






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