Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

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Disputed islands are Japan's: Shinzo Abe

TOKYO: Shinzo Abe, who piloted his Liberal Democratic Party to victory in Sunday's election, said there is no doubt about Japan's ownership of islands at the centre of a dispute with China.

"China is challenging the fact that (the islands) are Japan's inherent territory," said Abe, who is expected to become prime minister. "Our objective is to stop the challenge. We don't intend to worsen relations between Japan and China."

Meanwhile, Japanese Prime Minister Yoshihiko Noda on Sunday conceded defeat in the general election and said he was stepping down as leader from his humbled governing party.

"I will resign as the head of the Democratic Party of Japan because I take this result seriously," he told a press conference. "I want to deeply apologise as I could not produce results."

Noda was speaking after NHK television, citing forecasts based on both official results and its own exit polls, said the Liberal Democratic Party had won at least 255 seats with 95 seats undecided, against 39 seats for the DPJ.

The LDP is expected to easily secure a majority of the 480-seat chamber with New Komeito, its junior coalition partner, which is expected to win at least 25 seats, NHK said.

Asked why the DPJ suffered such a haemorrhaging of support, Noda said: "We were unable to live up to people's expectations when we came into government (in 2009)."

"Politicians must take responsibility for results. The biggest responsibility for such a severe defeat lies with me as the party leader."

- AFP/xq

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Google will alter search to end FTC antitrust inquiry, says report

The Federal Trade Commission may bring its two-year antitrust investigation of Google to a close by allowing the company to make voluntary changes to its search business, according to a report.

The search giant is said to be readying an announcement about changes to its use of "snippets," bits of text culled from sites such as Yelp and TripAdvisor and displayed in search results, Politico reports, citing unnamed sources. Yelp and others had charged Google with using their content without permission.

Google will also makes tweaks that will allow for easier porting of search-ad campaigns from Google to rival search services, Politico's sources said.

Politico suggested on Tuesday that the FTC may leave the search-related case to the European Commission, which has mounted an investigation of its own. Reuters reported on Tuesday that some Google competitors, sensing a possible defeat, are taking the case to the Justice Department.

Google and the FTC also look to be close to a settlement in a case involving so-called frand -- or standard essential -- patents owned by Google.

Politico said the FTC declined to comment on today's report about the search tweaks, and it said Google would provide only the following statement: "We continue to work cooperatively with the Federal Trade Commission and are happy to answer any questions they may have."

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Space Pictures This Week: Frosty Mars, Mini Nile, More

Photograph by Mike Theiss, National Geographic

The aurora borealis, also known as the northern lights, illuminates the Arctic sky in a recent picture by National Geographic photographer Mike Theiss.

A storm chaser by trade, Theiss is in the Arctic Circle on an expedition to photograph auroras, which result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere.

After one particularly amazing show, he wrote on YouTube, "The lights were dancing, rolling, and twisting, and at times looked like they were close enough to touch!" (Watch his time-lapse video of the northern lights.)

Published December 14, 2012

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School Safety Questioned After Conn. Shooting

Along with fire drills, schools have been conducting lockdown drills -- often known as active shooter drills -- since the Columbine massacre in 1999.

But safety officials do not agree yet on what teachers and students should do when a homicidal gunman invades their school.

At Sandy Hook Elementary School, teachers, staff and students had been drilled on how to handle such a situation.

"We practice it, and they knew what to do, and you just think about protecting the kids, and just doing the right thing," library clerk Mary Ann Jacob said.

She said had been drilled to send the kids in the library to a back closet between book shelves, a plan developed in advance.

"You have to have a certain amount of fire drills, and evacuation drills, and a certain amt of lockdown drills," she said. "Kids know the routine, and the teachers know the routine, and everyone has a spot in the room where they are supposed to go to."

Click here for more photos of the scene.

School safety expert Ken Trump told ABC News that he thinks the Sandy Hook teachers did what they could to protect their students.

"It does sound as though the teachers did everything humanly possible, down to risking their lives, to protect the children in this Connecticut school," Trump said.

Connecticut Shooting Tragedy: Two Brothers' Escape Watch Video

Connecticut Shooting Tragedy: The Investigation Watch Video

Connecticut Shooting Tragedy: Remembering the Victims Watch Video

The school's principal and five other adults died in the Sandy Hook school shooting in Newtown, Conn.

"Teaching kids to lock down, securing your rooms, and, in some cases, teachers stepping forth to protect the children at the risk of their own lives, is something that we see occurring more and more over the years in school safety," Trump said.

He and others particularly praised the actions of first grade teacher Kaitlin Roig, who locked her classroom door and barricaded herself and her 14 students in a locked bathroom.

But former SWAT officer Greg Crane told ABC News that he thinks existing lockdown procedures aren't sufficient.

"What she [Roig] did was a fantastic move," said Crane, who founded a school safety program called ALICE, which stands for alert, lock down, inform, counter, evacuate.

"Was she taught that move? Did every teacher know to lock the door and also barricade it? If that's the case, why weren't other teachers taught that?" Crane asked.

Most schools tell teachers to lock their doors and sit quietly until helps arrives, Crane said.

Typical are the procedures, obtained by ABCNews.com, outlined by a New Jersey school district that calls their drills "Lock Down Yellow."

Instructions to the students include:

"Go to the room nearest your location in the hallway.

"No one will be able to leave room for any reason.

"Silence must be maintained (Use of cell phones are not permitted).

"Make sure you are marked present.

"Do not leave the classroom until directed by PA System, telephone or by an administrator."

But Crane founded ALICE because he believed there was something wrong with the lock down-only policies in most schools.

"We've taught a generation of Americans to be passive and static and wait for police," said Crane, whose wife was an elementary school principal in Texas at the time of the Columbine attack.

"We don't recommend just locking a door because locked doors have been defeated before," Crane said. "Try to make yourself as hard a target as possible."

ALICE argues students and teachers should not be passive and that they should improvise. He even suggests they throw things are their attacker.

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Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

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Youths have similar ideals to govt, says ESM Goh

SINGAPORE: Singapore youths generally have the same ideals as that of the government, observed Emeritus Senior Minister Goh Chok Tong at the end of a national conversation session at the Marine Parade constituency.

Mr Goh said this will make it easier for the government to work together with the generation of the future.

"Supposing they come up with very different ideals from what we think should be for the prosperity and stability of Singapore. It's going to be very troublesome," he said.

"Supposing they had all argued about welfare state and so on, then that's very troublesome for us because we know that without resources, without economic growth and so on, a welfare state will lead us to ruins."

Some of the goals set by participants during the conversation with Marine Parade residents included a more cohesive society and more sustainable economic growth.

The 45 participants comprised youths and working adults.

Mr Goh felt that the society has, in recent years, been drifting without a clear sense of direction.

He added that having the same ideals does not mean goals can be reached if the society is divided.

Mr Goh said Singapore has never been more politically divided, so the Singapore Conversation is a very serious effort to build a new compact between the people and the government.

"The worry is as we emphasise more freedom for the people, (society) becomes more cosmopolitan, takes in more foreigners, immigrants and so on, (and) our society begins to loosen as a result of these new trends," he said.

"The old (generation) is getting smaller in proportion. The young (generation) is getting bigger, with different experiences... and if they don't get a new sense of bonding in working as a group, can you imagine how we move into the future?"

Mr Goh also pointed out even though ideals may be similar, young Singaporeans may disagree with the processes and priorities in policy-making.

Youths felt that at this stage of the conversation, ideals that surface would naturally be similar to the government. But they believed there is still space for disagreements.

"When the conversation is couched in very generic themes and terms, of course, we have the same broad general ideals and there is a consensus," said Chris Lim, a participant at the session.

"But when the minute details of policies are discussed, that's when differences will start to appear, in the ways of how we do it. This is a question that remains to be answered in the course of our national conversation."

This is the first time Mr Goh has attended the national conversation session.

He has been conducting several community conversations with his residents at Marine Parade.

Mr Goh explained that these conversations were more unstructured, where residents could discuss policy issues.

Lawrence Wong, committee member of Our Singapore Conversation, said he is satisfied with the progress and outreach, three months after the initiative started.

Mr Wong was also present at the session in Marine Parade.

He said: "We've been trying to reach out to as broad spectrum of society as possible, and I think we've had very good representation of people who come enthusiastically to share, and we've got very good ideas. There's certainly more that we can do."

Separately, at a session of Our Singapore Conversation held with the Malay Muslim community at Bukit Batok East, participants raised the issue of cultivating patriotism in every Singaporean, especially the younger generation.

"What is important to me also is that they talk about patriotism, which is something I did not find in the other conversations," said Minister of State for Social and Family Development Halimah Yacob.

"In this conversation, they say it is important within the context of building a strong national identity, reinforcing multi-culturalism, multi-racialism, that we are patriotic Singaporeans and how we continue to project that."

- CNA/xq

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Google's Ray Kurzweil hire could yield some good returns

Ray Kurzweil signing copies of his book, "The Singularity"

(Credit:
Dan Farber)

Google has brought on futurist and artificial intelligence expert Ray Kurzweil as director of engineering, and there could be some real returns on the company's high-profile hire.

In a statement, Kurzweil confirmed that he'd be joining Google. He noted that his interest in reading technology, artificial intelligence, driving
cars and those other things from the Jetsons lines up nicely with Google's efforts.

He said:

Google has demonstrated self-driving cars, and people are indeed asking questions of their
Android phones. It's easy to shrug our collective shoulders as if these technologies have always been around, but we're really on a remarkable trajectory of quickening innovation, and Google is at the forefront of much of this development.

Will Kurzweil be more than just a figurehead? Probably. Google will get some returns on its investment in Kurzweil for sure. Here are some of the positive side effects from Google's latest hire.

Talent and recruiting engineers. There aren't enough engineers to keep tech giants like Google, Microsoft, Apple and others happy. Saying you report to a futurist---even indirectly---will have credibility beyond stock options for most engineers.

Data centers, networks and algorithms need machine learning. Kurzweil's ideas get noticed because he's ahead of the curve and he focuses on simple practical systems. However, machine learning has implications for the network, Google's algorithms and the data center. Look no further than IBM and Watson for examples of how machine learning can have broad implications. Should Kurzweil boost machine learning, Google is likely to be able to draw a straight line between its infrastructure and its high-profile hire.

Language processing has big mobile implications. Kurzweil's knowhow could on reading and talking machines could easily make its way into Android, which is already becoming very helpful on many fronts.

Google's buzz-o-meter. Kurzweil's work can easily be applied to the company's efforts for self-driving cars and its high-tech glasses that could become popular at some point. Kurzweil gives Google some science fiction becomes reality cred. The buzz is hard to measure, but it's certainly not a bad perk for the company.

In his book, "The Singularity Is Near: When Humans Transcend Biology," Kurzweil offered his view of how science fiction becomes reality:

"In this new world, there will be no clear distinction between human and machine, real reality and virtual reality. We will be able to assume different bodies and take on a range of personae at will. In practical terms, human aging and illness will be reversed; pollution will be stopped; world hunger and poverty will be solved. Nanotechnology will make it possible to create virtually any physical product using inexpensive information processes and will ultimately turn even death into a soluble problem."

Kurzweil expects that artificial intelligence will develop far beyond the human mind in a few decades, leading to what he calls "The Singularity," in which technology changes profoundly alter human history. "The implications include the merger of biological and nonbiological intelligence, immortal software-based humans, and ultra-high levels of intelligence that expand outward in the universe at the speed of light," he wrote.

This story first appeared on ZDNet. Additional reporting by Dan Farber.

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Space Pictures This Week: Frosty Mars, Mini Nile, More

Photograph by Mike Theiss, National Geographic

The aurora borealis, also known as the northern lights, illuminates the Arctic sky in a recent picture by National Geographic photographer Mike Theiss.

A storm chaser by trade, Theiss is in the Arctic Circle on an expedition to photograph auroras, which result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere.

After one particularly amazing show, he wrote on YouTube, "The lights were dancing, rolling, and twisting, and at times looked like they were close enough to touch!" (Watch his time-lapse video of the northern lights.)

Published December 14, 2012

Read More..

School Shooting: Officials Seek Details on Gunman

The FBI is in at least three states interviewing relatives and friends of the elementary school gunman who killed 20 children, seven adults and himself, trying to put together a better picture of the shooter and uncover any possible explanation for the massacre, ABC News has learned.

The authorities have fanned out to New Jersey, Connecticut and Massachusetts to interview relatives of Adam Lanza, 20, and his mother, who was one of Lanza's shooting victims.

CLICK HERE for full coverage of the tragedy at the elementary school.

The victims died Friday when Lanza invaded Sandy Hook Elementary School in Newtown, Conn., and sprayed staff and students with bullets, officials said. Lanza also was found dead in the school.

Lt. Paul Vance said 18 children died in the school and two more died later in a hospital.

Six adults also were slain, bringing the total to 26. Among them was the school's principal, Dawn Hochsprung, multiple sources told ABC News. Another adult victim was teacher Vicki Soto, her cousin confirmed.

In addition to the casualties at the school, Lanza's mother, Nancy Lanza, was killed in her home, federal and state sources told ABC News.

According to sources, Lanza shot his mother in the face, then left his house armed with at least two semi-automatic handguns, a Glock and a Sig Sauer, and a semi-automatic rifle. He was also wearing a bulletproof vest.

READ: Connecticut Shooter Adam Lanza: 'Obviously Not Well'

Newtown Teacher Kept 1st Graders Calm During Massacre Watch Video

Newtown School Shooting: What to Tell Your Kids Watch Video

Lanza then drove to the elementary school and continued his rampage, authorities said.

It appeared that Lanza died from what was believed to be a self-inflicted gunshot wound. The rifle was found in his car.

"Evil visited this community today," Gov. Dan Malloy said at a news conference Friday evening.

CLICK HERE for more photos from the scene.

In the early confusion surrounding the investigation, federal sources initially identified the suspect as Adam's older brother Ryan Lanza, 24. Identification belonging to Ryan Lanza was found at the shooting scene, federal sources told ABC News.

Ryan Lanza soon took to Facebook to say he was alive and not responsible for the shooting. He later was questioned by police.

During the rampage, first-grade teacher Kaitlin Roig, 29, locked her 14 students in a class bathroom and listened to "tons of shooting" until police came to help.

"It was horrific," Roig said. "I thought we were going to die."

She said that the terrified kids were saying, "I just want Christmas. ... I don't want to die. I just want to have Christmas."

A tearful President Obama said Friday that there was "not a parent in America who doesn't feel the overwhelming grief that I do."

The president had to pause to compose himself after saying these were "beautiful little kids between the ages of 5 and 10."

As he continued with his statement, Obama wiped away tears from each eye. He has ordered flags flown as half staff.

It is the second worst mass shooting in U.S. history, exceeded only by the Virginia Tech shooting in 2007 when 32 were killed before the shooter turned the gun on himself. The carnage in Connecticut exceeded the 1999 Columbine High School shooting in which 13 died and 24 were injured.

Friday's shooting came three days after masked gunman Jacob Roberts opened fire in a busy Oregon mall, killing two before turning the gun on himself.

The Connecticut shooting occurred at the Sandy Hook Elementary School, which includes 450 students in grades K-4. The town is located about 12 miles east of Danbury, Conn.

The massacre prompted the town of Newtown to lock down all its schools and draw SWAT teams to the school, authorities said.

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