False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

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Pertapis children's home using music to boost academic performance

SINGAPORE: Pertapis children's home is trying to raise its residents' academic achievements through using music as educational therapy.

As part of the programme, the children learn to play various musical instruments.

It is one way to help them express themselves and focus better on their studies as a result.

The home is also getting help from partners like Hwa Chong Institution for lessons on playing other instruments.

At the end of the music therapy programme, the children will be performing in a concert next month, where their family members are invited to attend.

Pertapis has seen positive changes in the children.

Haloyah Atana, administrator at Pertapis said: "We have seen slight improvements in their studies such as increase in marks in the exams. They are also more forthcoming in seeking help.They are more open and able to manage their daily needs."

- CNA/xq

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How Apple got serious about style

Humble beginnings -- an early conceptual modular Apple tablet from 1982.

(Credit:
Harmut Esslinger, Frog Design)

When Frog Design founder Hartmut Esslinger met Steve Jobs in 1982, it sparked a chain of events that monumentally changed Apple's design philosophy forever. It wasn't just a change in how future products would look -- Esslinger ushered in a change of mindset and a unified design language across products. Esslinger's new book, "Design Forward: Creative Strategies for Sustainable Change," available today in the U.S., delivers some fascinating insights into those crucial early years at Apple.

The dialect that emerged from that period, known as the Snow White design language, influenced dozens of Apple devices starting with the Apple IIc in 1984 and lasting until the Macintosh IIfx in 1990.

Our gallery below starts off with a range of computers that earned Frog Design a hefty annual contract and a role as a leader in Apple's product design process. The two companies didn't just create computers, however; they went beyond and created a mock
tablet, computer phone, flat-screen devices, and more.

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Picture Archive: Making Mount Rushmore, 1935-1941

Photograph from Rapid City Chamber of Commerce/National Geographic

There's no such thing as Presidents' Day.

According to United States federal government code, the holiday is named Washington's Birthday, and has been since it went nationwide in 1885.

But common practice is more inclusive. The holiday expanded to add in other U.S. presidents in the 1960s, and the moniker Presidents' Day became popular in the 1980s and stuck. It may be that George Washington (b. February 22, 1732) andAbraham Lincoln (b. February 12, 1809) still get the lion's share of attention—and appear in all the retail sale ads—on the third Monday in February, but the popular idea is that all 44 presidents get feted.

Mount Rushmore is a lot like that one day a year writ large—and in granite. It's carved 60 feet (18 meters) tall and 185 feet (56 meters) wide, from Washington's right ear to Lincoln's left.

The monument's sculptor, Gutzon Borglum, grew up in Idaho, a first-generation American born to Danish parents. He studied art in France and became good friends with Auguste Rodin. Borglum mostly worked in bronze, but in the early 1910s he was hired to carve the likenesses of Confederate leaders into Stone Mountain in Georgia.

He was about to be fired from that job for creative differences about the same time that a South Dakota historian named Doane Robinson had an idea. Robinson wanted to have a monument carved into the Black Hills of South Dakota, maybe Western historical figures like Chief Red Cloud and Lewis and Clark, each on their own granite spire. (Plan a road trip in the Black Hills.)

Robinson hired Borglum and gave him carte blanche. Borglum was looking for something with national appeal, so he chose to depict four presidents: George Washington, Thomas Jefferson, Theodore Roosevelt, and Abraham Lincoln.

Borglum wanted to represent the first 150 years of the nation's history, choosing four presidents as symbols of their respective time periods. He took a tour of western South Dakota, searching for an ideal canvas.

The sculptor was looking for three things: a surface strong enough to sculpt, a mountain big enough to hold several figures, and a mountain face that received morning sunlight. Mount Rushmore fit the bill and was already part of a national forest, so it was easy to set aside as a national memorial.

Work started in 1927. Calvin Coolidge attended the dedication ceremony. It took 14 years to finish the carving, conducted mostly in summertime because of the area's harsh winters.

There were approximately 30 workers on the mountain at any give time. In total about 400 had worked on it by the time the monument was finished. Though the project involved thousands of pounds of dynamite and perilous climbs, not a single person died during the work.

Borglum himself died of natural causes in 1941, though, just six months before the project was declared "closed as is" by Congress that Halloween. His son Lincoln—named for his father's favorite president—took over.

In the photo above, a worker refines the details of Washington's left nostril.

About 90 percent of the mountain was carved using dynamite, which could get within 3 to 5 inches (8 to 13 centimeters) of the final facial features. For those last few inches, workers used what was known as the honeycomb method: Jackhammer workers pounded a series of three-inch-deep holes followed up by chiselers who knocked off the honeycomb pieces to get the final shape. Then carvers smoothed the "skin's" surface.

—Johnna Rizzo

February 16, 2013

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Vatican Raises Possibility of Early March Conclave

The Vatican raised the possibility Saturday that the conclave to elect the next pope might start sooner than March 15, the earliest date possible under current rules that require a 15-20 day waiting period after the papacy becomes vacant.

Vatican spokesman The Rev. Federico Lombardi said that the Vatican rules on papal succession are open to interpretation and that "this is a question that people are discussing."

"It is possible that church authorities can prepare a proposal to be taken up by the cardinals on the first day after the papal vacancy" to move up the start of conclave, Lombardi said.

He explained that the 15-20 day rule is in place to allow time for the arrival of "all those (cardinals) who are absent" to take part in the conclave in the usual circumstances of convening after a pope dies. But in this case, the cardinals already know that this pontificate will end on Feb. 28 with the resignation of Pope Benedict XVI, and therefore can get to Rome in plenty of time to take part in the conclave, Lombardi said.

L'Osservatore Romano Vatican Pool/Getty Images

The date of the conclave's start is important because Holy Week begins March 24, with Palm Sunday Mass followed by Easter Sunday on March 31. In order to have a new pope in place in time for the most solemn liturgical period on the church calendar, he would need to be installed as pope by Sunday, March 17. Given the tight time-frame, speculation has mounted that some sort of arrangement would be made to start the conclave earlier than a strict reading of the law would allow.

Questions about the start of the conclave have swirled ever since Benedict announced on Feb. 11 that he would retire, the first pontiff in 600 years to abdicate rather than stay in office until death. As a result, his decision has created a host of questions about how the Vatican will proceed, given that its procedures for the so-called "sede vacante" — or vacant seat — period between papacies won't begin with a pope's death.

Lombardi also gave more details about Benedict's final audiences and plans for retirement, saying already 35,000 people have requested tickets for his final general audience to be held in St. Peter's Square on Feb. 27. He said Benedict would spend about two months in the papal summer retreat at Castel Gandolfo south of Rome immediately after his abdication, to allow enough time for renovations to be completed on his retirement home — a converted monastery inside the Vatican walls.

That means Benedict would be expected to return to the Vatican, no longer as pope, around the end of April or beginning of May, Lombardi said.

He was asked if and when the pope would meet with his successor and whether he would participate in his installation Mass; like many open questions about the end of Benedict's papacy, both issues simply haven't yet been resolved, Lombardi said.

———

Follow Nicole Winfield at www.twitter.com/nwinfield

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Russian meteor will teach us about future bigger hits

You wait years for a space rock and then two come along at once. Just hours before an asteroid is due to almost graze Earth, a meteor has exploded over the Russian region of Chelyabinsk, injuring hundreds of people and damaging nearby buildings.

Studying the impact could give clues to future hits from rarer, bigger space rocks, which are bound to occur.

The impact occurred at 0320 GMT today, the very day that astronomers are anticipating the close fly-by of asteroid 2012 DA14, although there is thought to be no connection between the two events. "This is a remarkable coincidence," says Stephen Lowry, an astronomer at the University of Kent in Canterbury, UK.

Details of the strike are still emerging, but pictures and video shared on social media offer clues to the meteor's make-up and origin. "It's certainly smaller than 50 metres and larger than a metre," says Simon Green of the Open University in Milton Keynes, UK. It appears to have exploded as it entered the Earth's atmosphere, creating a shock wave that shattered windows, damaged buildings and apparently collapsed the roof and walls of zinc factory.

The Russian Academy of Sciences says the meteor weighed 10 tons and entered the atmosphere at a speed of at least 54,000 kilometres per hour, exploding between 30 to 50 kilometres above the ground. Reports from Russia also say that more than 900 hundred people have been injured, mostly by broken glass. Reports also suggest there are no fatalities, although two people are in intensive care.

Astronomers will want to recover any fragments of the meteorite that hit the ground. "You'll find them strewn over a large area. There may be some very large fragments but there will be many smaller ones spread over kilometres," says Green. "We can study the science of the bodies and learn more about the bigger ones, which are the real threat."

The much smaller Sutter's Mill meteorite that fell on California last year yielded many fragments that showed it was a very rare type of rock called a CM chondrite.

Strange coincidence

It is not unusual for meteors the size of the one that fell in Chelyabinsk to hit the Earth, though most end up falling into the sea unnoticed. "Depending on its size, it might be something that hits every few years or every few decades," says Green.

Although the odds of an unrelated meteor impacting on the same day as an asteroid fly-by seem astronomically high, experts seem sure the two objects are not linked, especially as the meteor hit over 12 hours before the expected fly-by. "2012 DA14 approaches from the south at quite a steep angle relative to the Earth's equatorial plane, so Russia being in the northern hemisphere makes [a link] extremely unlikely," says Lowry. "If this had been a southern hemisphere impact, serious questions would have been being asked."

One of the European Space Agency's satellites managed to spot the vapour trail of the meteor as it entered the atmosphere. The agency itself has also confirmed that there is no link with asteroid 2012 DA14, on course to fly past Earth at height of around 27,000 kilometres at 1925 GMT.

There are a large number of videos of the Russian meteor strike because it is common for Russian drivers to use dashboard-mounted cameras to prove liability in car accidents. The footage should allow astronomers to retrace the meteor's flight path and identify its origin, as well as any other space rocks that might be related. One possibility is that the meteor split off from a larger object. "It is possible that a collision could have happened further back in its orbit," says Lowry.

If the remnants remained on the same orbit, then they too could impact Earth, although that is unlikely as the planet has most likely moved out of the path of any potential secondary strike by now. "It is possible a parent fragment could hit Earth, but the probability decreases rapidly as time passes."

Read more: Meteorite hunters: Join the space rock rush

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Eurozone returns to trade surplus

BRUSSELS: The 17-nation eurozone posted a 2012 trade surplus of 81.8 billion euros ($108 billion), more than reversing a deficit of 15.7 billion euros in 2011, official data showed Friday.

For December, the eurozone had a trade surplus of 11.7 billion euros, down from 13 billion euros in November, as exports fell 1.8 percent and imports by 3.0 percent, the Eurostat agency said.

For the wider 27-member EU, December showed a trade deficit of some 700 million euros after a deficit of 1.9 billion euros in November, as exports dropped 1.9 percent and imports were down 1.6 percent.

For 2012, the full EU suffered a trade deficit of 104.6 billion euros, improving from a deficit of 162.7 billion euros in 2011.

Eurostat said that for the January-November 2012 period, the EU 27 deficit on energy increased to 388.6 billion euros from 354.6 billion euros in the same period a year earlier, while the bloc enjoyed a surplus in manufactured goods of 330.8 billion euros, up from 224.9 billion euros.

Among member states for the same period, powerhouse Germany had the biggest trade surplus at 174.6 billion euros, followed by the Netherlands, Ireland and the Czech Republic.

Britain had the largest deficit at 152.9 billion euros, with France, Spain and Greece next.

- AFP/al

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Uh oh: Nintendo sold 57,000 Wii U units in the U.S. in January

Nintendo's Wii U had a rough January, CNET has learned.

Nintendo sold only 57,000
Wii U units in the U.S. in January, a person familiar with NPD's game industry sales data has confirmed to CNET. The leading console maker during the period, Microsoft, sold 281,000 units in January.

Gamasutra was first to report that
Wii U sales were sluggish in January. That publication's source said only that January sales were "well under" 100,000 units.

The Wii U's trouble in January stands in stark contrast to its predecessor, the Wii. In its first January on store shelves in 2007, Nintendo sold 435,000 console units.

That Nintendo is having trouble selling Wii U units is nothing new. The company's CEO Satoru Iwata last month characterized Wii U sales as "not bad." That came just days before Microsoft and Nintendo announced their console unit sales in December. During that period, Microsoft sold nearly one million more consoles.

The Wii U's troubles negatively affected Nintendo's earnings for the nine-month period ended December 31. The company said that it sold only 3 million Wii U units since its launch in November, adding that upcoming games, including new entries in the Legend of Zelda franchise, could "help Nintendo regain momentum for Wii U."

Still, that a console that has been on store shelves for just three months is selling so few units is shocking. It's something that gamers would expect from unknown game companies, but that it's a Nintendo issue, especially given its recent successes, is surprising.

CNET has contacted Nintendo for comment. We will update this story when we have more information.

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Why We Walk … and Run … And Walk Again to Get Where We're Going

You have to get to a bus stop to catch the once-an-hour express ... or to a restaurant to meet a friend ... or to a doctor's office. You've got maybe a half a mile to cover and you're worried you'll be late. You run, then you stop and walk, then run some more.

But wait. Wouldn't it be better to run the whole way?

Not necessarily.

A new study by an assistant professor of mechanical engineering at Ohio State University tests the theory that people subconsciously mix walking and running so they get where they need to. The idea is that "people move in a manner that minimizes energy consumption," said the professor, Manoj Srinivasan.

Srinivasan asked 36 subjects to cover 400 feet (122 meters), a bit more than the length of a football field. He gave them a time to arrive at the finish line and a stopwatch. If the deadline was supertight, they ran. If they had two minutes, they walked. And if the deadline was neither too short nor too far off, they toggled between walking and running.

The takeaway: Humans successfully make the walk-run adjustment as they go along, based on their sense of how far they have to go. "It's not like they decide beforehand," Srinivasan said. (Get tips, gear recommendations, and more in our Running Guide.)

The Best Technique for "the Twilight Zone"

"The mixture of walking and running is good when you have an intermediate amount of time," he explained. "I like to call it 'the Twilight Zone,' where you have neither infinite time nor do you have to be there now."

That ability to shift modes served ancient humans well. "It's basically an evolutionary argument," Srinivasan said. A prehistoric human seeking food would want to move in a way that conserves some energy so that if food is hard to find, the hunter won't run out of gas—and will still be able to rev it up to escape predators.

The study, published on January 30 in the Journal of the Royal Society Interface, doesn't answer that question of how we make such adjustments.

Runners: Take a Break if You Need It

The mix of walking and running is also something that nonelite marathoners are familiar with. Covering 26.2 miles might take less of a toll if the runner stops running from time to time, walks a bit, then resumes a jogging pace. "You use less energy overall and also give yourself a bit of a break," Srinivasan noted. (Watch: An elite marathoner on her passion for running.)

One take-home lesson is: Runners, don't push it all the time. A walk-run mix will minimize the energy you expend.

Lesson two: If you're a parent walking with your kid, and the kid lags behind, then runs to catch up, then lags again, the child isn't necessarily trying to annoy you. Rather, the child is perhaps exhibiting an innate ability to do the walk-run transition.

Potential lesson three: The knowledge that humans naturally move in a manner that minimizes energy consumption might be helpful in designing artificial limbs that feel more natural and will help the user reduce energy consumption.

The big question for Manoj Srinivasan: Now that he has his walk-run theory, does he consciously switch between running and walking when he's trying to get somewhere? "I must admit, no," he said. "When I want to get somewhere, I just let the body do its thing." But if he's in a rush, he'll make a mad dash.

"Talk to you tomorrow," he signed off in an email to National Geographic News. "Running to get to teaching now!"

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Falling Meteor Causes Blast, Injures Hundreds

A massive meteor shower slammed into Earth near the Russian city of Chelyabinsk, located about 1,000 miles east of Moscow in the Ural Mountains.

Dashboard cameras captured a blinding flash of light streaking across the sky. Moments later, the fragments smashed into the ground. The impact, and the sonic boom of the meteor entering the atmosphere, shattered windows around the city and knocked over a wall at a zinc factory.

Witnesses said they thought a war had broken out.

"I saw a body moving in the skies. In a moment there came a flash - we first thought it was fireworks but a moment later we saw a trace as if from the rocket followed by an explosion in a couple of minutes. The window broke ... tea, bread, water - everything fell on the floor," one restaurant waiter in Chelyabinsk said.

Officials told the Russian news agency Interfax that more than 500 people were injured, most by broken glass. Of the 12 people hospitalized, at least three of them were in serious condition.

One scientist told Russian television the meteor was a big one, weighing perhaps tens of tons, but stressed that it was not related to the asteroid that is expected to buzz close to Earth later today.

Regional officials said the one large fragment fell in a lake, but debris had been reported in three parts of Russia and in Kazakhstan.

Schools in the region closed for the day after most of the windows were blown out, citing freezing temperatures, which were below zero degrees Fahrenheit during the day.

Debris from the meteor was found in three sites around the country, but emergency services say ground zero was Chebarkul Lake, just west of Chelyabinsk.

The meteor knocked out cell phone networks, but electricity and water supplies were not affected. Rosatom said all its nuclear power facilities were functioning normally.

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