False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

Read More..

Pope calls for Church to "renew", thousands flock to Angelus

VATICAN CITY: Pope Benedict XVI called on the Church and its faithful on Sunday to "renew themselves" as tens of thousands of pilgrims and tourists attended his penultimate Angelus prayers.

Families with young children, pensioners and nuns packed into the square in the sunshine said they had come to pay their respects to the pope, make their goodbyes or just share in a historic event ahead of Benedict's resignation.

Groups of scouts held up banners reading "We have loved you so much!" and "We will be with you... always" and said they wanted to show Benedict that his shock decision to stand down on February 28 had not shaken their faith in him.

"He has done it for the good of the Church, and will keep serving us," said Germana Blaiotta.

A serene-looking Benedict waved to the crowds and thanked them for turning out in such large numbers, calling it a "sign of affection and spiritual closeness", as the onlookers called out "viva il papa" (long live the pope).

The Vatican said over 50,000 people had turned out to see the 85-year-old pope, while local authorities put the number at over 100,000.

Benedict, whose surpise announcement last Monday that he would step down after eight years rocked the Church, called on the world's faithful to "refocus on God by disowning pride and egoism".

His words were seemed by some to hold a veiled reference to internal bickering within the Church in recent months, as well as the jostle for power as cardinals from all over the world prepare to vote in his successor.

"Benedict did everything for the Church, he was always in the limelight but they did nothing but criticise him and try and undermine him. Whoever follows him will have to have strong nerves," said Margherita Yager, 61, from Germany.

Christine Renier, a 48-year-old teacher from Paris, said she was in Rome on holiday and had wanted to see the pontiff before he retires to a secluded monastery behind the Vatican walls for a life of contemplation.

"It is a sad day, but I think Benedict was actually too rigid and lost many faithful among the young. I'm hoping for a pope who can throw out the bureaucracy and get back to the Church's roots, perhaps an African," she said.

Amid speculation over which of the 117 cardinals in the running might snap up the Vatican's top job, Italian media said Cardinal Angelo Scola, the Archbishop of Milan, was among the favourites backed by Benedict.

After meeting the pope on Saturday, Scola said Benedict had told him "you have to become a light for everyone", a phrase pounced on by the media as a clue.

"Significant words which will be weighed by everyone," said the Repubblica, while La Stampa agreed they were "meaningful words".

At St Peter's Square, tourists snapping souvenir photographs of Benedict on their smart phones said he may have revolutionised the papacy.

"This is a moment which will go down in history. He's opened the door to future resignations and I cannot see anyone suffering through an old age as pope again. From now on they'll retire," said Michele Agostino, 66.

Later Sunday, the pontiff will start a week-long spiritual retreat and have only very few public engagements before he formally steps down -- the first to resign voluntarily in 700 years.

Benedict will receive Italian President Giorgio Napolitano on February 23, celebrate his last Angelus prayer on February 24 and hold a final audience in St Peter's Square with tens of thousands of followers on February 27.

- AFP/xq

Read More..

Russian meteorite: The conspiracy theories

A strange time for a military attack?

(Credit:
CNN; screenshot by Chris Matyszczyk/CNET)

A good hearty conspiracy theory can shine a sharp light on two of humanity's most enduring traits.

One, of course, is humanity's boundless imagination. The other is humanity's essential suspicion of humanity.

So while you might be deeply immersed in Bill Nye's explanation of the Russian meteorite, those with darker sensibilities have filled the Web with their fears and hauntings about the phenomenon.

There are few nations with greater awareness of dark sensibilities than Russia. The fact that there seems to be little evidence of meteorite fragments on the ground has encouraged some Russians to offer their own suspicions.

As the Toronto Globe and Mail reports, nationalist leader Vladimir Zhirinovsky hasn't been slow to offer something of a Hot War perspective.

"It's not meteors falling. It's a new weapon being tested by the Americans," he was quoted as saying.

We know from our recent experience of North Korea that weapons testing is an imprecise science.

But if you were an American in the mood to test a weapon, would Chelyabinsk, Russia, be your very first choice of place for the experiment?

Perhaps Tallahassee; Area 51; and Bialystok, Poland, were all unavailable due to prior commitments. Or perhaps it wasn't the Americans, but, say, the North Koreans, who mistook Chelyabinsk for, say, Chelsea.

Zhirinovsky's rather emotionally manipulative offering was countered by Russia's Emergency Ministry, which dedicated itself to an extensive rebuttal of his belief (and that of others) that this was some sort of military thing. The rebuttal? "Rubbish."

But that wasn't going to put off the local media, was it? Not only do they have papers to sell, they also have theories to expound to a troubled nation and world.

So, as The Atlantic reports, the local Znak newspaper accepted that this was a meteorite but insisted the explosion was caused by military defense blowing it up.

More Technically Incorrect

Yes, of course it has a source in the military. You thought it didn't?

Though I've watched a few movies in which exciting things happen, I don't find it easy to imagine that some sort of terrestrially created missile-laden aircraft could really explode a meteorite in such a manner.

It is easier to imagine, though, that politicians like Zhirinovsky might take the opportunity to foment a little rage.

Indeed, Alex Jones' infamously well-guarded Infowars site offered that Zhirinovsky insisted that America -- in the person of Secretary of State John Kerry -- had tried to give Russia advance notice of its "attack."

The Drudge Report led me to a piece at Foreign Policy that explained that Sergey Lavrov, Russia's foreign minister, simply hadn't called Kerry back.

Which all suggests that Russia isn't, after all, living in fear of an attack from the U.S. Especially one over Chelyabinsk.

On balance, I prefer to currently believe Nye. He is the science guy, after all. And science guys know scientific events when they see them.

I hope.

Read More..

Pictures: What the Presidents Brought Home

Photograph by Bill Ray, Time Life Pictures/Getty Images

When paleontologist Paul Olsen (pictured left, in 1970 at 17 years old) first started looking for dinosaurs in 1967, he never dreamed that he'd end up the subject of White House memos between President Richard Nixon and his senior advisers.

Or that one of the dinosaur footprints he discovered would find its way into a presidential collection.

But that's exactly what happened when Olsen and his friend Tony Lessa (right) successfully lobbied for the creation of a park in 1970 near Livingston, New Jersey (map).

The future park, located in a quarry owned by Walter Kidde Precision Instruments, was a budding paleontologist's dream.

The area was covered in dinosaur footprints, such as ones made by Eubrontes gigantis (pictured), and some of them were more than 200 million years old.

"The footprints are very well preserved in that particular spot," said Olsen, now at Columbia University in New York. And the arrangement of some of them—many small footprints associated with one larger set—indicated behaviors that included parental care, he said.

It took Olsen and Lessa two and a half years to get the area designated as a park, but once they did, an Olsen family friend started writing letters to the White House to see if the boys could meet the President.

"[Presidential speechwriter] William Safire said he didn't want President Nixon to be associated with the concept of a dinosaur," said Olsen. The White House staff discussed this while dealing with the Vietnam War, going so far as to write memos on the situation, he said.

Olsen and Lessa never got their meeting with the President. But Nixon ended up sending the teenagers presidential commendations.

Olsen sent the President a cast of the E. gigantis footprint as a thank you. The cast now resides at the Nixon Presidential Library and Museum in Yorba Linda, California.

The actual footprint fossils, stored in a shed at the park, have walked off. "No one knows what happened to them," Olsen said.

February 17, 2013

Read More..

Gun Ban Would Protect More Than 2,200 Firearms

Congress' latest crack at a new assault weapons ban would protect more than 2,200 specific firearms, including a semi-automatic rifle that is nearly identical to one of the guns used in the bloodiest shootout in FBI history.

One model of that firearm, the Ruger .223 caliber Mini-14, is on the proposed list to be banned, while a different model of the same gun is on a list of exempted firearms in legislation the Senate is considering. The gun that would be protected from the ban has fixed physical features and can't be folded to be more compact. Yet the two firearms are equally deadly.

"What a joke," said former FBI agent John Hanlon, who survived the 1986 shootout in Miami. He was shot in the head, hand, groin and hip with a Ruger Mini-14 that had a folding stock. Two FBI agents died and five others were wounded.

Hanlon recalled lying on the street as brass bullet casings showered on him. He thought the shooter had an automatic weapon.

Both models of the Ruger Mini-14 specified in the proposed bill can take detachable magazines that hold dozens of rounds of ammunition. "I can't imagine what the difference is," Hanlon said.

President Barack Obama has called for restoring a ban on military-style assault weapons and limiting the size of ammunition magazines.

Gun Owners Rally State Capitals Across Country Watch Video

A bill introduced last month by Sen. Dianne Feinstein, D-Calif. would ban 157 specific firearms designed for military and law enforcement use and exempt others made for hunting purposes. It also would ban ammunition magazines that hold more than 10 rounds.

Yet there are firearms that would be protected under Feinstein's proposal that can take large capacity magazines like the ones used in mass shootings that enable a gunman to fire dozens of rounds of ammunition without reloading.

Feinstein said in a written response to questions from The Associated Press that the list of more than 2,200 exempted firearms was designed to "make crystal clear" that the bill would not affect hunting and sporting weapons.

The December shooting at an elementary school in Newtown, Conn., that left 26 students and educators dead forced Washington to focus on curbing gun violence, a risky political move not tried in decades.

The gun industry, which is fighting any sort of ban, says gun ownership in the U.S. is the highest it's ever been, with more than 100 million firearms owners.

Obama and Vice President Joseph Biden have traveled around the country in an effort to gain support for new laws. Feinstein's proposal is the only sweeping piece of legislation designed to ban assault weapons currently being considered.

But some gun experts say the lists of banned and exempted firearms show a lack of understanding and expertise of guns.

"There's no logic to it," said Greg Danas, president of a Massachusetts-based expert witness business and firearms ballistic laboratory. "What kind of effect is it going to have?"

Feinstein's bill defines an assault weapon as a semi-automatic firearm with a detachable magazine that has one of several military characteristics that are specified in her legislation. Examples of those characteristics include a pistol grip, which makes a firearm easier to hold, and a forward grip, which makes the firearm easier to stabilize to improve accuracy. The definition is similar to the one in Congress' original ban on assault weapons, which went into effect in 1994 and was widely criticized for outlawing firearms based on cosmetic features.

Read More..

False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

Read More..

Pertapis children's home using music to boost academic performance

SINGAPORE: Pertapis children's home is trying to raise its residents' academic achievements through using music as educational therapy.

As part of the programme, the children learn to play various musical instruments.

It is one way to help them express themselves and focus better on their studies as a result.

The home is also getting help from partners like Hwa Chong Institution for lessons on playing other instruments.

At the end of the music therapy programme, the children will be performing in a concert next month, where their family members are invited to attend.

Pertapis has seen positive changes in the children.

Haloyah Atana, administrator at Pertapis said: "We have seen slight improvements in their studies such as increase in marks in the exams. They are also more forthcoming in seeking help.They are more open and able to manage their daily needs."

- CNA/xq

Read More..

How Apple got serious about style

Humble beginnings -- an early conceptual modular Apple tablet from 1982.

(Credit:
Harmut Esslinger, Frog Design)

When Frog Design founder Hartmut Esslinger met Steve Jobs in 1982, it sparked a chain of events that monumentally changed Apple's design philosophy forever. It wasn't just a change in how future products would look -- Esslinger ushered in a change of mindset and a unified design language across products. Esslinger's new book, "Design Forward: Creative Strategies for Sustainable Change," available today in the U.S., delivers some fascinating insights into those crucial early years at Apple.

The dialect that emerged from that period, known as the Snow White design language, influenced dozens of Apple devices starting with the Apple IIc in 1984 and lasting until the Macintosh IIfx in 1990.

Our gallery below starts off with a range of computers that earned Frog Design a hefty annual contract and a role as a leader in Apple's product design process. The two companies didn't just create computers, however; they went beyond and created a mock
tablet, computer phone, flat-screen devices, and more.

Read More..

Picture Archive: Making Mount Rushmore, 1935-1941

Photograph from Rapid City Chamber of Commerce/National Geographic

There's no such thing as Presidents' Day.

According to United States federal government code, the holiday is named Washington's Birthday, and has been since it went nationwide in 1885.

But common practice is more inclusive. The holiday expanded to add in other U.S. presidents in the 1960s, and the moniker Presidents' Day became popular in the 1980s and stuck. It may be that George Washington (b. February 22, 1732) andAbraham Lincoln (b. February 12, 1809) still get the lion's share of attention—and appear in all the retail sale ads—on the third Monday in February, but the popular idea is that all 44 presidents get feted.

Mount Rushmore is a lot like that one day a year writ large—and in granite. It's carved 60 feet (18 meters) tall and 185 feet (56 meters) wide, from Washington's right ear to Lincoln's left.

The monument's sculptor, Gutzon Borglum, grew up in Idaho, a first-generation American born to Danish parents. He studied art in France and became good friends with Auguste Rodin. Borglum mostly worked in bronze, but in the early 1910s he was hired to carve the likenesses of Confederate leaders into Stone Mountain in Georgia.

He was about to be fired from that job for creative differences about the same time that a South Dakota historian named Doane Robinson had an idea. Robinson wanted to have a monument carved into the Black Hills of South Dakota, maybe Western historical figures like Chief Red Cloud and Lewis and Clark, each on their own granite spire. (Plan a road trip in the Black Hills.)

Robinson hired Borglum and gave him carte blanche. Borglum was looking for something with national appeal, so he chose to depict four presidents: George Washington, Thomas Jefferson, Theodore Roosevelt, and Abraham Lincoln.

Borglum wanted to represent the first 150 years of the nation's history, choosing four presidents as symbols of their respective time periods. He took a tour of western South Dakota, searching for an ideal canvas.

The sculptor was looking for three things: a surface strong enough to sculpt, a mountain big enough to hold several figures, and a mountain face that received morning sunlight. Mount Rushmore fit the bill and was already part of a national forest, so it was easy to set aside as a national memorial.

Work started in 1927. Calvin Coolidge attended the dedication ceremony. It took 14 years to finish the carving, conducted mostly in summertime because of the area's harsh winters.

There were approximately 30 workers on the mountain at any give time. In total about 400 had worked on it by the time the monument was finished. Though the project involved thousands of pounds of dynamite and perilous climbs, not a single person died during the work.

Borglum himself died of natural causes in 1941, though, just six months before the project was declared "closed as is" by Congress that Halloween. His son Lincoln—named for his father's favorite president—took over.

In the photo above, a worker refines the details of Washington's left nostril.

About 90 percent of the mountain was carved using dynamite, which could get within 3 to 5 inches (8 to 13 centimeters) of the final facial features. For those last few inches, workers used what was known as the honeycomb method: Jackhammer workers pounded a series of three-inch-deep holes followed up by chiselers who knocked off the honeycomb pieces to get the final shape. Then carvers smoothed the "skin's" surface.

—Johnna Rizzo

February 16, 2013

Read More..

Vatican Raises Possibility of Early March Conclave

The Vatican raised the possibility Saturday that the conclave to elect the next pope might start sooner than March 15, the earliest date possible under current rules that require a 15-20 day waiting period after the papacy becomes vacant.

Vatican spokesman The Rev. Federico Lombardi said that the Vatican rules on papal succession are open to interpretation and that "this is a question that people are discussing."

"It is possible that church authorities can prepare a proposal to be taken up by the cardinals on the first day after the papal vacancy" to move up the start of conclave, Lombardi said.

He explained that the 15-20 day rule is in place to allow time for the arrival of "all those (cardinals) who are absent" to take part in the conclave in the usual circumstances of convening after a pope dies. But in this case, the cardinals already know that this pontificate will end on Feb. 28 with the resignation of Pope Benedict XVI, and therefore can get to Rome in plenty of time to take part in the conclave, Lombardi said.

L'Osservatore Romano Vatican Pool/Getty Images

The date of the conclave's start is important because Holy Week begins March 24, with Palm Sunday Mass followed by Easter Sunday on March 31. In order to have a new pope in place in time for the most solemn liturgical period on the church calendar, he would need to be installed as pope by Sunday, March 17. Given the tight time-frame, speculation has mounted that some sort of arrangement would be made to start the conclave earlier than a strict reading of the law would allow.

Questions about the start of the conclave have swirled ever since Benedict announced on Feb. 11 that he would retire, the first pontiff in 600 years to abdicate rather than stay in office until death. As a result, his decision has created a host of questions about how the Vatican will proceed, given that its procedures for the so-called "sede vacante" — or vacant seat — period between papacies won't begin with a pope's death.

Lombardi also gave more details about Benedict's final audiences and plans for retirement, saying already 35,000 people have requested tickets for his final general audience to be held in St. Peter's Square on Feb. 27. He said Benedict would spend about two months in the papal summer retreat at Castel Gandolfo south of Rome immediately after his abdication, to allow enough time for renovations to be completed on his retirement home — a converted monastery inside the Vatican walls.

That means Benedict would be expected to return to the Vatican, no longer as pope, around the end of April or beginning of May, Lombardi said.

He was asked if and when the pope would meet with his successor and whether he would participate in his installation Mass; like many open questions about the end of Benedict's papacy, both issues simply haven't yet been resolved, Lombardi said.

———

Follow Nicole Winfield at www.twitter.com/nwinfield

Read More..